diff --git a/.changeset/silent-bees-sing.md b/.changeset/silent-bees-sing.md
new file mode 100644
index 000000000..10d5602e7
--- /dev/null
+++ b/.changeset/silent-bees-sing.md
@@ -0,0 +1,5 @@
+---
+'slate': patch
+---
+
+set_node operations did not invert correctly after serialization
diff --git a/packages/slate/src/transforms/general.ts b/packages/slate/src/transforms/general.ts
index a3d17a4ec..49fd0757a 100644
--- a/packages/slate/src/transforms/general.ts
+++ b/packages/slate/src/transforms/general.ts
@@ -182,7 +182,7 @@ export const GeneralTransforms: GeneralTransforms = {
       }
 
       case 'set_node': {
-        const { path, newProperties } = op
+        const { path, properties, newProperties } = op
 
         if (path.length === 0) {
           throw new Error(`Cannot set properties on the root node!`)
@@ -204,6 +204,13 @@ export const GeneralTransforms: GeneralTransforms = {
           }
         }
 
+        // properties that were previously defined, but are now missing, must be deleted
+        for (const key in properties) {
+          if (!newProperties.hasOwnProperty(key)) {
+            delete node[key]
+          }
+        }
+
         break
       }
 
diff --git a/packages/slate/src/transforms/node.ts b/packages/slate/src/transforms/node.ts
index 4fac582a8..2a4d2d061 100644
--- a/packages/slate/src/transforms/node.ts
+++ b/packages/slate/src/transforms/node.ts
@@ -631,7 +631,8 @@ export const NodeTransforms: NodeTransforms = {
           }
 
           if (props[k] !== node[k]) {
-            properties[k] = node[k]
+            // Omit new properties from the old property list rather than set them to undefined
+            if (node.hasOwnProperty(k)) properties[k] = node[k]
             newProperties[k] = props[k]
           }
         }
diff --git a/packages/slate/test/operations/set_node/remove-null.tsx b/packages/slate/test/operations/set_node/remove-null.tsx
new file mode 100644
index 000000000..918d65809
--- /dev/null
+++ b/packages/slate/test/operations/set_node/remove-null.tsx
@@ -0,0 +1,28 @@
+/** @jsx jsx */
+import { jsx } from 'slate-hyperscript'
+import { Transforms, Editor } from 'slate'
+
+export const input = (
+  <editor>
+    <element>
+      <text key />
+    </element>
+  </editor>
+)
+
+export const operations = [
+  {
+    type: 'set_node',
+    path: [0, 0],
+    properties: { key: true },
+    newProperties: { key: null },
+  },
+]
+
+export const output = (
+  <editor>
+    <element>
+      <text />
+    </element>
+  </editor>
+)
diff --git a/packages/slate/test/operations/set_node/remove-omit.tsx b/packages/slate/test/operations/set_node/remove-omit.tsx
new file mode 100644
index 000000000..615c5c89a
--- /dev/null
+++ b/packages/slate/test/operations/set_node/remove-omit.tsx
@@ -0,0 +1,28 @@
+/** @jsx jsx */
+import { jsx } from 'slate-hyperscript'
+import { Transforms, Editor } from 'slate'
+
+export const input = (
+  <editor>
+    <element>
+      <text key />
+    </element>
+  </editor>
+)
+
+export const operations = [
+  {
+    type: 'set_node',
+    path: [0, 0],
+    properties: { key: true },
+    newProperties: {},
+  },
+]
+
+export const output = (
+  <editor>
+    <element>
+      <text />
+    </element>
+  </editor>
+)
diff --git a/packages/slate/test/operations/set_node/remove-undefined.tsx b/packages/slate/test/operations/set_node/remove-undefined.tsx
new file mode 100644
index 000000000..0c8cc7d96
--- /dev/null
+++ b/packages/slate/test/operations/set_node/remove-undefined.tsx
@@ -0,0 +1,28 @@
+/** @jsx jsx */
+import { jsx } from 'slate-hyperscript'
+import { Transforms, Editor } from 'slate'
+
+export const input = (
+  <editor>
+    <element>
+      <text key />
+    </element>
+  </editor>
+)
+
+export const operations = [
+  {
+    type: 'set_node',
+    path: [0, 0],
+    properties: { key: true },
+    newProperties: { key: undefined },
+  },
+]
+
+export const output = (
+  <editor>
+    <element>
+      <text />
+    </element>
+  </editor>
+)
diff --git a/packages/slate/test/transforms/setNodes/basic-structure/can-be-serialized.tsx b/packages/slate/test/transforms/setNodes/basic-structure/can-be-serialized.tsx
new file mode 100644
index 000000000..7e9cc31bd
--- /dev/null
+++ b/packages/slate/test/transforms/setNodes/basic-structure/can-be-serialized.tsx
@@ -0,0 +1,25 @@
+/** @jsx jsx */
+import assert from 'assert'
+import { Editor, Transforms, Operation } from 'slate'
+import { jsx } from '../../..'
+
+export const run = (editor: Editor) => {
+  Transforms.setNodes(editor, { key: true }, { at: [0] })
+  const [op] = editor.operations
+  const roundTrip: Operation = JSON.parse(JSON.stringify(op))
+  assert.deepStrictEqual(op, roundTrip)
+}
+export const input = (
+  <editor>
+    <block>
+      <text />
+    </block>
+  </editor>
+)
+export const output = (
+  <editor>
+    <block key>
+      <text />
+    </block>
+  </editor>
+)
diff --git a/packages/slate/test/transforms/setNodes/basic-structure/invert-after-serialization.tsx b/packages/slate/test/transforms/setNodes/basic-structure/invert-after-serialization.tsx
new file mode 100644
index 000000000..4e7218194
--- /dev/null
+++ b/packages/slate/test/transforms/setNodes/basic-structure/invert-after-serialization.tsx
@@ -0,0 +1,25 @@
+/** @jsx jsx */
+import { Editor, Transforms, Operation } from 'slate'
+import { jsx } from '../../..'
+
+export const run = (editor: Editor) => {
+  Transforms.setNodes(editor, { key: true }, { at: [0] })
+  const [op] = editor.operations
+  const roundTrip: Operation = JSON.parse(JSON.stringify(op))
+  const inverted = Operation.inverse(roundTrip)
+  editor.apply(inverted)
+}
+export const input = (
+  <editor>
+    <block>
+      <text />
+    </block>
+  </editor>
+)
+export const output = (
+  <editor>
+    <block>
+      <text />
+    </block>
+  </editor>
+)