diff --git a/packages/slate-react/src/components/content.js b/packages/slate-react/src/components/content.js
index 5ff5f13bc..1c8f20b02 100644
--- a/packages/slate-react/src/components/content.js
+++ b/packages/slate-react/src/components/content.js
@@ -105,6 +105,7 @@ class Content extends React.Component {
     nodeRef: React.createRef(),
     nodeRefs: {},
     contentKey: 0,
+    nativeSelection: {}, // Native selection object stored to check if `onNativeSelectionChange` has triggered yet
   }
 
   /**
@@ -237,7 +238,35 @@ class Content extends React.Component {
 
     // If the Slate selection is unset, but the DOM selection has a range
     // selected in the editor, we need to remove the range.
-    if (selection.isUnset && rangeCount && this.isInEditor(anchorNode)) {
+    // However we should _not_ remove the range if the selection as
+    // reported by `getSelection` is not equal to `this.tmp.nativeSelection`
+    // as this suggests `onNativeSelectionChange` has not triggered yet (which can occur in Firefox)
+    // See: https://github.com/ianstormtaylor/slate/pull/2995
+
+    const propsToCompare = [
+      'anchorNode',
+      'anchorOffset',
+      'focusNode',
+      'focusOffset',
+      'isCollapsed',
+      'rangeCount',
+      'type',
+    ]
+
+    let selectionsEqual = true
+
+    for (const prop of propsToCompare) {
+      if (this.tmp.nativeSelection[prop] !== native[prop]) {
+        selectionsEqual = false
+      }
+    }
+
+    if (
+      selection.isUnset &&
+      rangeCount &&
+      this.isInEditor(anchorNode) &&
+      selectionsEqual
+    ) {
       removeAllRanges(native)
       updated = true
     }
@@ -288,39 +317,43 @@ class Content extends React.Component {
       // Otherwise, set the `isUpdatingSelection` flag and update the selection.
       updated = true
       this.tmp.isUpdatingSelection = true
+      removeAllRanges(native)
 
-      if (!IS_FIREFOX) {
-        removeAllRanges(native)
-
-        // COMPAT: IE 11 does not support `setBaseAndExtent`. (2018/11/07)
-        if (native.setBaseAndExtent) {
-          // COMPAT: Since the DOM range has no concept of backwards/forwards
-          // we need to check and do the right thing here.
-          if (isBackward) {
-            native.setBaseAndExtent(
-              range.endContainer,
-              range.endOffset,
-              range.startContainer,
-              range.startOffset
-            )
-          } else {
-            native.setBaseAndExtent(
-              range.startContainer,
-              range.startOffset,
-              range.endContainer,
-              range.endOffset
-            )
-          }
+      // COMPAT: IE 11 does not support `setBaseAndExtent`. (2018/11/07)
+      if (native.setBaseAndExtent) {
+        // COMPAT: Since the DOM range has no concept of backwards/forwards
+        // we need to check and do the right thing here.
+        if (isBackward) {
+          native.setBaseAndExtent(
+            range.endContainer,
+            range.endOffset,
+            range.startContainer,
+            range.startOffset
+          )
         } else {
-          native.addRange(range)
+          native.setBaseAndExtent(
+            range.startContainer,
+            range.startOffset,
+            range.endContainer,
+            range.endOffset
+          )
         }
+      } else {
+        native.addRange(range)
       }
 
       // Scroll to the selection, in case it's out of view.
       scrollToSelection(native)
 
-      // Then unset the `isUpdatingSelection` flag after a delay.
+      // Then unset the `isUpdatingSelection` flag after a delay, to ensure that
+      // it is still set when selection-related events from updating it fire.
       setTimeout(() => {
+        // COMPAT: In Firefox, it's not enough to create a range, you also need
+        // to focus the contenteditable element too. (2016/11/16)
+        if (IS_FIREFOX && this.ref.current) {
+          this.ref.current.focus()
+        }
+
         this.tmp.isUpdatingSelection = false
 
         debug.update('updateSelection:setTimeout', {
@@ -355,6 +388,12 @@ class Content extends React.Component {
     let el
 
     try {
+      // COMPAT: In Firefox, sometimes the node can be comment which doesn't
+      // have .closest and it crashes.
+      if (target.nodeType === 8) {
+        return false
+      }
+
       // COMPAT: Text nodes don't have `isContentEditable` property. So, when
       // `target` is a text node use its parent node for check.
       el = target.nodeType === 3 ? target.parentNode : target
@@ -481,12 +520,24 @@ class Content extends React.Component {
     const window = getWindow(event.target)
     const { activeElement } = window.document
 
+    const native = window.getSelection()
+
     debug.update('onNativeSelectionChange', {
-      anchorOffset: window.getSelection().anchorOffset,
+      anchorOffset: native.anchorOffset,
     })
 
     if (activeElement !== this.ref.current) return
 
+    this.tmp.nativeSelection = {
+      anchorNode: native.anchorNode,
+      anchorOffset: native.anchorOffset,
+      focusNode: native.focusNode,
+      focusOffset: native.focusOffset,
+      isCollapsed: native.isCollapsed,
+      rangeCount: native.rangeCount,
+      type: native.type,
+    }
+
     this.props.onEvent('onSelect', event)
   }, 100)