This is an extremely dangerous query, because it includes the user
table twice, along-side two other potentially large tables,
role_assignments and user_enrolments.
The solution is to rewrite the query so that:
1. The subquery is JOINed, not WHERE ... INed. Typically query
optimisers handle the JOIN case better.
2. Before the join was role-assignments <-> users <-> subquery.
That is, everything was linked to u.id.
Now the linking is role-assignments <-> subquery <-> users,
so the SELECT DISTINT eu1_u.id FROM {enrolled users} is central.
That seems to send a strong hint to the query optimiser about
a good order to execute the query.
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