The Patcher will not run on systems with Avast AntiVirus installed. This is because Avast falsely (!) detects the patcher as a virus. Some AntiVirus applications for some reason detect a false positive for AutoIt Binaries (the coding language the Patcher is writtten in). Nevertheless, I guarantee that my files are virus free!
In order to execute the patcher you have to temporarily disable Avast and enable it after installation again. Note that you need to do so every time you update or reapply the patcher!
Another solution would be to add the patcher files to the whitelistet files in your AntiVirus software.
Other AntiVirus applications might show this behavior as well and the steps described above need to be applied in order to install the patcher.